News
Bacteria to Power AI: Nebraska Scientists Pursue Bio-Hybrid Computing
Source: news.unl.edu
Published on November 3, 2025
Updated on November 3, 2025

Bio-Hybrid Computing: The Future of Sustainable AI
Scientists at the University of Nebraska–Lincoln are pioneering a groundbreaking approach to computing: bio-hybrid systems powered by bacteria. This innovative research aims to address the growing energy demands of artificial intelligence by leveraging the natural intelligence found in living cells.
The project, led by Associate Professor Sasitharan Balasubramaniam, focuses on using bacteria like Shewanella oneidensis to perform complex machine learning tasks. By establishing a direct communication link with these microorganisms, the team hopes to offload significant computational work from traditional silicon-based systems.
The Promise of Bacteria in AI Computing
Bacteria offer a unique advantage over other biological candidates for computing, such as neurons. Unlike neurons, which are delicate and raise ethical concerns, bacteria are resilient and easier to maintain. Their intricate network structures resemble artificial neural networks, making them ideal for integration into advanced computing systems.
The research team plans to use a technique called 'electrogenetics' to stimulate specific genes within the bacteria. This process triggers chemical reactions that perform computational calculations, producing electrical outputs that computers can interpret. Essentially, the bacteria act as biological co-processors, taking on some of the heavy lifting from silicon chips.
Energy Efficiency and Sustainability
One of the primary goals of this research is to reduce the energy consumption of AI systems. Traditional machine learning tools are notorious for their high power demands, with data centers consuming vast amounts of electricity globally. By leveraging bacteria, the team aims to significantly reduce the computational footprint of AI, paving the way for more sustainable technology.
Bacteria also offer practical advantages over neurons. Their robustness and ease of maintenance make them a more viable candidate for integration into novel computing systems. This approach seeks to tap into the inherent intelligence that nature has perfected over billions of years of evolution.
Future Applications and Beyond
The potential applications of bio-hybrid computing extend far beyond energy-efficient data centers. Balasubramaniam envisions revolutionary future applications, such as 'smart pills' that house engineered bacteria with AI capabilities. These implantable devices could detect and control harmful pathogens, bridging healthcare and technology in innovative ways.
Ultimately, this project aims to redefine computer architecture by integrating living cells into computing systems. While challenges remain in translating laboratory concepts into scalable infrastructure, the potential for radically energy-efficient computing makes this a breakthrough worth watching.
Conclusion
The idea of bacteria-powered AI might sound futuristic, but the underlying logic is compelling. As AI's energy demands continue to rise, innovative solutions like bio-hybrid computing offer a pathway to more sustainable and versatile technology. This research serves as a reminder that groundbreaking leaps in high-tech innovation can emerge from the ancient world of microorganisms.